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Core Nutritionals Load GDA
With the advent of Core LOAD, Core Nutritionals has effectively changed the meaning of glucose-disposal agent (GDA). While most GDAs on the market are single-pathway or single-mechanism formulas with sub-clinical serving sizes, Core LOAD targets multiple pathways and mechanisms through either clinical or supra-clinical serving sizes. And most importantly, Core LOAD reaches these pathways through several non-redundant key ingredients that surgically target both glycogenic (glycogen-creating) and lipolytic (lipid/fat tissue-mitigating) pathways.
Core LOAD’s success as a GDA is due to its key ingredients – and specifically, the major pathways of glycogen storage and lipid metabolism they alter. Specifically, increasing the translocation of GLUT4 from the cell nucleus (its inner portion) to the periphery (its outer portion), thereby increasing the transportation of glucose into the cell; by inhibiting PPAR-Gamma2 and other critical lipogenic/lipolytic genes and gene pathways; by altering the response to glucose ingestion at the cellular level; and by altering other critical messengers in both the glycogenic and lipolytic pathways.
While other GDAs may target similar pathways, Core LOAD contains several ingredients that target these pathways through several different, non-redundant mechanisms. Essentially, we have taken every possible step to maximize your body’s glycogen storage, rather than relying on a single ingredient approach. Perhaps more importantly, we have utilized ingredients such a CGA (chlorogenic acid – a component of green coffee extract) in ways and serving sizes that blow the competition away. While serving sizes as small as 300mg of GGA have been shown to assist in healthy weight management, we included a savage 2g serving! That serving is also anywhere from 3-10x the serving size found in clinical research assessing CGA’s impact on glucose homeostasis and glycogen formation.
Now, the critical question, not just for CGA, but for all glucose disposal agents is this: why is “disposing” of glucose important? What does that even mean. Let’s break this down in two ways. Let’s consider the first way as (attempting) to increase lean tissue; and the other avoiding non-lean tissue. When you consume carbohydrates, your body breaks those carbohydrates down until they eventually reach the plasma (blood) as glucose – blood sugar. Blood sugar is then diverted to cells for consumption in bodily processes.
Our bodies divert glucose to both muscle cells (good) and fat cells (bad). In terms of the good, lean tissue-increasing effects, the key ingredients in Core LOAD will assist your body in creating glycogen. Think of glycogen like NOS for a car: a car can certainly run on fuel alone, but adding NOS to the mix greatly boosts the vehicle’s speed. For short bursts of maximal or near-maximal effort exercise, glycogen functions as your body’s fuel source – in addition to filling muscle bellies to provide them a “full,” 3D look. Maximizing glycogen storage also acts like an insurance policy against lipogenic (fat tissue-creating) action: the more glycogen stored in muscle, the less glucose shuttled to adipose cells or to the liver.
In terms of the bad, your body also diverts glucose to adipose (fat) cells – but not for energy consumption, but energy storage. Consider fat cell’s the long term storage bunker of your body: your body puts glucose there to withdraw it in times of need. Core LOAD’s key ingredients inhibit the process in non-redundant, synergistic ways – from inhibiting glucose uptake at the gastrointestinal level (to stabilize plasma glucose, which diminishes uptake in adipose cells) to diminishing the activity of key lipogenic (fat mass increasing) genes.
Core GDA Supp Facts
- Green Coffee Extract (Coffea robusta) (bean) (50% Chlorogenic acid)
Coffee is widely recognized as not only the most consumed psychoactive compound on earth, but perhaps also the most consumed plant material in general. Due to the extent of coffee consumption by humans, several species of coffee beans, along with their bioactive constituents, have been research targets for a number of therapeutic pathways. The most abundant polyphenol in coffee is Chlorogenic acid (CGA). An abundance of data suggests that CGA has numerous physiological properties, and that its most potent physiological effects are hypoglycemic (blood sugar-lowering) and lipolytic/anti-lipogenic in nature. Recent evidence demonstrates that CGA is a powerful and novel glucose modulator, in vivo, in both healthy and diseased populations.
- GS4 Plus® Gymnema sylvestre Extract (leaves) (25% gymnemic acids)
Gymnema sylvestre is a plant endemic to the tropical and sub-tropical regions of Southeast Asa, including India and China. In these countries, G. sylvestre functions as a treatment for many pathological conditions, including diabetes and hypercholesterolemia – in fact, the Ayurvedic name for G. sylevestre is “Gurmar,” or “destroyer of sugars.” The principle bioactives in G. sylvestre, gymnemic acids, are concentrated highly in the leaves and have been isolated and observed for their glucose shuttling properties.
- Berbis aristata Extract (bark) (97% berberine)
Berberis aristata, is a shrub belonging to the family Berberidaceae and the genus Berberis, found in many parts of Eurasia and the Americas. The bark and bark extracts of the plant have been used traditionally as an antibacterial and antifungal preparation and as a hypoglycaemic, anti-diuretic, and vasodilator. The use of both B. aristata and its principal constituent, berberine, is widespread in traditional medicinal systems throughout history. Berberine is also now a prominent ingredient in dietary supplement formulations and a research target for numerous pathological conditions.
- Banaba Extract (Lagerstroemia speciose)(leaf)(20% corosolic acids)
Lagerstroemia speciosa is a flowering tree of the Lagerstroemia genus that is native to large portions of south east Asia, India and the Phillipines, and its bark and leaves have a historical tradition in folk medicine for the treatment of diabetes mellitus. Banaba (L. speciosa’s common name) has been used as a folk medicine to treat diabetes in various parts of the world, primarily southeast Asia. The hypoglycemic effect of aqueous (hot water) and methanol extracts have been demonstrated in many human studies. Most studies have focused on corosolic acid, the primary bioactive constituent of L. speciosa – and the compound for which Core LOAD’s banaba is standardized.